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noun 
  1. An act of knocking down or the condition of being knocked down.
  2. An overwhelming blow.
  3. (genetics) A genetically modified organism that carries one or more genes in its chromosomes that has been made less active or had its expression reduced.
  4. (genetics) The use of a reagent such as an oligonucleotide with sequence complementary to an active gene or its mRNA transcript, to interfere with the expression of said gene.
  5. (nautical) The condition of a sailboat being pushed abruptly to horizontal, with the mast parallel to the water surface.
adjective 
  1. powerful enough to overwhelm or knock down
  2. reduced in price
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